Homeostatine

Homeostatine® is a natural active cosmetic ingredient from Provital. Through an innovative process, Homeostatine® will recover and maintain homeostasis in the dermal extra-cellular matrix to produce a better moisturized, more elastic, firmer skin with noticeably less wrinkles.

Homeostatine® combines two botanicals into a novel skin care complex. This unique complex is derived from the seeds of the Andean tree Caesalpinia spinosa and the algae known as Enteromorpha compressa. Homeostatine activity is due to the combined action of galactomannan from Caesalpinia spinosa and marine pentasaccharide (MPS) from Enteromorpha compressa.

Within this novel hydro-colloidal three-dimensional matrix, these two components function at two different levels. Galactomannans are high molecular weight polysaccharides with natural hydrating functions. The hydrocolloid, galactomannan structure provides the moisturizing matrix and maintains contact with the stratum corneum for the release of the MPS. The MPS molecules are very small and can penetrate the epidermis to promote the synthesis of collagen and function as metabolism mediators within the dermis. Within the dermis, the MPS will function to inhibit the synthesis of Metalloproteinases (MMP) as well as the synthesis of pro-inflammatory mediators such as cytokines. When MMP is inhibited, the degradation of collagen and other extracellular components is reduced. The result is less wrinkled, rejuvenated, and firmer skin.

Homeostatine Activity:
- Increases the production of dermal collagen and other ECM components in fibroblasts.
- Inhibits the synthesis of metalloproteinases (MMP).
- Inhibits the synthesis of pro-inflammatory mediators.

Recommended Usage: 2% - 3% for early wrinkles and 2% - 5% for aged skin.

Physical Form: Pale yellow opalescent viscous liquid

INCI Name: Water (and) Glycerin (and) Enteromorpha Compressa Extract (and) Caesalpinia Spinosa Gum

pH: 4.5 – 5.5

Odor: Characteristic herbal scent

Solubility: Soluble in water

Storage and Shelf-life: Keep product in a clean, cool and dark place. Shelf-life should be 12 - 18 months at room temperature (50-77F / 10-25C).

Caution: Do not directly apply onto your skin.
This product should be added to the formulation at cool-down at the recommended usage rate.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.